Beilstein J. Org. Chem.2016,12, 2136–2144, doi:10.3762/bjoc.12.203
functional groups into its native structure [10][11]. Such chemically modified oligonucleotides are useful intermediates for their subsequent functionalization through post-synthetic protocols [11][12][13]. Within a post-synthetic strategy, a nucleotideanalog is modified with a reactive functional group
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Graphical Abstract
Figure 1:
Template-directed dynamic chemistry assay for the attachment of modified nucleobase monomers to an ...
Beilstein J. Org. Chem.2014,10, 1967–1980, doi:10.3762/bjoc.10.205
of a conformational analysis show that the alkylation/acylation can be effectively used for tuning the pyrrolidine conformation over the whole pseudorotation cycle.
Keywords: conformation; NMR; nucleic acids; nucleotideanalog; phosphonic acid; pseudorotation; pyrrolidine; Introduction
Nucleotides
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Graphical Abstract
Figure 1:
Examples of biologically active acyclic and cyclic nucleotide analogs.